Pituitary stalk interruption syndrome as a cause of severe growth retardation and hypogonadotropic hypogonadism in an adolescent: a clinical case
Received: 2026-06-11 16:56:08
Published: 2026-05-21
Abstract
Pituitary stalk interruption syndrome (PSIS) is a rare congenital disorder with an incidence of approximately 0.5 cases per 1,000,000 live births, characterised by hypopituitarism of varying severity. We report a clinical case of a 17-year-old male presenting with severe growth retardation and absent pubertal development. Investigations revealed hypogonadotropic hypogonadism, growth hormone deficiency, and the classical MRI triad of PSIS: adenohypophysis hypoplasia, pituitary stalk aplasia, and ectopic neurohypophysis. The case highlights the importance of early diagnosis and the need for regular growth monitoring and hormonal screening in children with delayed physical development.
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