THE EFFECT OF DISORDERS OF THE HEPATOENTERIC CIRCULATION OF BILE ACIDS ON THE DEGREE OF LITHOGENICITY OF BILE
Received: 2026-06-21 11:40:22
Published: 2025-12-21
Abstract
Disorders of hepatoenteric bile acid circulation lead to pronounced changes in the chemical composition of bile, which is key to the development of gallstone disease. Rupture or decrease in enterohepatic bile acid efficiency is accompanied by decreased liver secretion volume, decreased bile acid concentration, and increased cholesterol levels, initiating bile nucleation. Prolonged changes in bilirubin metabolism and disruption of mucosal and serosal transport systems in the gallbladder increase the risk of stone formation. Experimental data confirm the critical role of hepatobiliary circulation and demonstrate pathogenetic mechanisms underlying lithogenic bile formation in its disruption.
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